After a few recnt projects, I'm falling more in love with the idea of settings where there are no humans. Instead, I'm thinking more of multicultural/multi-racial settings, where the default race isn't specifically defined as human, but is instead defined as a mongrel hybrid of the setting's original races. Then throwing in the twist that there are "mongrel/human" supremacist groups who claim to be the most powerful in the land, only because they are the most numerous...certainly not because they are the most pure.
I come to this again as I consider a fantasy version of The Law. But I need to make sure the base version is complete first...and I need to eliminate some university projects before I can go much further on that.